发明名称 |
METHOD AND COMPOSITION FOR THE TREATMENT OF CANCER |
摘要 |
We have discovered that the administration of a G1 and/or S phase drug such as beta-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a beta-lapachone, or a derivative or analog thereof. |
申请公布号 |
EP1181013(A4) |
申请公布日期 |
2004.07.07 |
申请号 |
EP20000922237 |
申请日期 |
2000.04.14 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
PARDEE, ARTHUR, B.;LI, CHIANG, J.;LI, YOU-ZHI |
分类号 |
C07D311/92;A61K31/122;A61K31/337;A61K31/35;A61K31/352;A61K31/4184;A61K31/427;A61K31/437;A61K31/704;A61K31/7042;A61K38/00;A61K45/00;A61K45/06;A61P35/00 |
主分类号 |
C07D311/92 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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