发明名称 |
PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE |
摘要 |
The present invention provides a method of preparing particles with polymorp h and size control of a pharmaceutical compound, the method including the step s of: (1) providing pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particl e size of the particles is less than 7~m. The present invention further provid es a polymorphic form of itraconazole.
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申请公布号 |
CA2498043(A1) |
申请公布日期 |
2004.07.01 |
申请号 |
CA20032498043 |
申请日期 |
2003.08.04 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
KIPP, JAMES E.;WERLING, JANE;DOTY, MARK J.;SRIRAM, RAJARAM;WONG, JOSEPH CHUNG TAK;REBBECK, CHRISTINE L. |
分类号 |
A61K9/00;A61K31/495;(IPC1-7):A61K9/00;A61K9/127;A61K9/14 |
主分类号 |
A61K9/00 |
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