| 发明名称 |
Use of nitriles as inhibitors of non-proteolytic enzymes |
| 摘要 |
<p>The present invention is related to the use of a compound as an inhibitor of or to a nonproteolytic enzyme, whereby the compound has the structure of formula (I): A-B-C-D wherein: A is selected from the group comprising: <CHEM> B is either present or absent, but if B is present B is <CHEM> C is <CHEM> D is selected from the group comprising -(CH2)rC(O)H, -(CH2)r'C IDENTICAL N, -(CH2)rNHNHC(O)NRA'RA'', -C(CH2)rC(O)(CH2)r'C(O)ORA', -(CH2)rC(O)(CH2)r'C(O)NRA'RA'', -(CH2)rCH(OH)(CH2)r'C(O)U, -(CH2)rC(O)W-(CH2)rC(O)CH2W, -(CH2)rC(O)haloalkyl, and -(CH2)rC(O)(CH2)r'CHN2.</p> |
| 申请公布号 |
EP1433779(A1) |
申请公布日期 |
2004.06.30 |
| 申请号 |
EP20020028801 |
申请日期 |
2002.12.23 |
| 申请人 |
JERINI AG |
发明人 |
KNOLLE, JOCHEN;SCHUTKOWSKI, MIKE;HUMMEL, GERD;TRADLER, THOMAS;JOBRON, LAURENCE;CHRISTNER, CLAUDIA;STRAGIES, ROLAND |
| 分类号 |
A61P43/00;C07D207/16;C07D209/18;C07D209/42;C07D215/36;C07D317/66;C07D333/34;C07D333/38;C07D333/60;C07D409/12;(IPC1-7):C07C255/25;A61K31/16;G01N33/00;C07C271/22;C07C323/44;C07C335/16;C07C307/10;C07C255/24;C07C255/58;C07C335/12;C07C335/18;C07C311/10 |
主分类号 |
A61P43/00 |
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