Mikanolide derivatives, their preparation and therapeutic uses

摘要

The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom.