| 摘要 |
<p>A method for resolving emulsions produced in preparation of pharmaceuticals and other bioprocessing applications involving fermentation, such emulsions containing fermentation product including a pharmaceutical that is desired to be separated from the emulsion, is disclosed. The method comprises adding to such emulsion a demulsifying amount of (1) the reaction product formed by heating lower alkanolamines and a fatty composition selected from the group consisting of fatty oils, fatty acids and mixtures thereof in a fatty composition to lower alkanolamine acid equivalent to molar ratio of from about 1:0.6 to about 1:4 and at a temperature within the range of about 150 DEG C to about 250 DEG C, and (2) alkoxylated amines selected from the group consisting of ethoxylated amines having from two to about four amino groups, propoxylated amines having from two to about four amino groups and mixtures thereof. Compositions comprising the mixture of the reaction product and the alkoxylated amines are also disclosed.</p> |
