| 摘要 |
Packing materials useful in applications such as liquid chromatography and solid phase extraction, as well as processes for producing such packing materials are described. The packing materials are based on chemically modified diamond powders. The surfaces of the diamond powders are attached with hydrocarbon, amino, carboxylic acid, or sulfonic acid groups through C-C, C-N, or C-S single bonds. The residual groups can be solely hydroxyl groups or solely hydrogen atoms. The stability of the packing materials allows regeneration of columns at pH>14 for protein separation. With hydrogen atoms as the residual groups for reverse phase diamond packings, the non-specific interaction associated with silica, polymeric, or graphitic packings can be largely eliminated. With hydroxyl groups as the residual groups for ion exchangers based on diamond powders, the non-specific interaction associated with hydrophobic sites can be largely eliminated.
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