发明名称 |
CONVERSION OF APOPTOTIC PROTEINS |
摘要 |
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members. |
申请公布号 |
WO2004052920(A2) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003US39676 |
申请日期 |
2003.12.11 |
申请人 |
THE BURNHAM INSTITUTE |
发明人 |
REED, JOHN, C.;ZHANG, XIAO-KUN;GUO, BIN;LIN, BINGZHEN;KOLLURI, SIVA, KUMAR |
分类号 |
A61K38/00;A61K38/17;A61K39/395;C07K16/28;G01N33/50 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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