发明名称 |
Process for the production of alkoxycarbonyl-dipeptides intermediates in the synthesis of the lisinopril |
摘要 |
Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.
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申请公布号 |
US6031112(A) |
申请公布日期 |
2000.02.29 |
申请号 |
US19990237071 |
申请日期 |
1999.01.25 |
申请人 |
P.F.C. ITALIANA S.R.L. |
发明人 |
CANNATA, VINCENZO;MERLI, VALERIANO;SAGUATTI, STEFANO |
分类号 |
C07K1/06;A61K38/00;C07K1/08;C07K5/068;(IPC1-7):C07D207/08;C07D263/04 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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