发明名称 |
WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME |
摘要 |
Compounds having the formula (1): <CHEM> wherein R<1> represents an alkyl or alkenyl group, R<2> and R<3> each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R<2> and R<3> may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represents a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to pharmaceutical compositions containing them. These compounds have inhibitory activity against IL-1 beta production, high water solubility and good oral absorbability.
|
申请公布号 |
EP1431293(A1) |
申请公布日期 |
2004.06.23 |
申请号 |
EP20020768055 |
申请日期 |
2002.09.25 |
申请人 |
KOWA CO., LTD. |
发明人 |
KYOTANI, YOSHINORI;KOSHI, TOMOYUKI;SHIGYO, HIROMICHI;YOSHIZAKI, HIDEO;KITAMURA, TAKAHIRO;TAKEMURA, SHUNJI;YASUOKA, KYOKO;TOTSUKA, JUNKO;SATO, SEIICHI |
分类号 |
C07D237/14;A61K31/50;A61K31/501;A61P1/04;A61P9/00;A61P19/02;A61P19/10;A61P29/00;A61P31/04;A61P37/02;A61P43/00;C07D237/24;(IPC1-7):C07D237/14 |
主分类号 |
C07D237/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|