发明名称 |
METHOD FOR PRODUCING A MAMMAL PROVIDED WITH RESISTANCE TO AN ALPHA-HERPES VIRUS MEDIATED INFECTION AND MAMMAL OBTAINED BY IMPLEMENTING SAID METHOD AND SAID MAMMAL'S PROGENY |
摘要 |
The invention concerns a method for producing a mammal belonging to a non-human species made resistant by germinal transgenesis to an alpha-herpes virus mediated infection, for which the HveC or nectin-1 polypeptide constitutes a functional receptor. The method consists in introducing by insertion or homologous recombination into the genome of the cells constituting the mammal's germinal line, a transgene enabling expression of a chimeric protein consisting of an extracellular domain of nectin-1 or HveC or one of its parts and an immunoglobulin crystallzable fragment, in a suitable expression system. |
申请公布号 |
WO2004035775(A3) |
申请公布日期 |
2004.06.17 |
申请号 |
WO2003FR03024 |
申请日期 |
2003.10.14 |
申请人 |
FRANCE HYBRIDES;ETSURO, ONO;TOSHIMITSU, UEDE |
发明人 |
ETSURO, ONO;TOSHIMITSU, UEDE |
分类号 |
A01K67/027;C07K14/705;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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