发明名称 |
Compound targeted for specific cells with reduced systemic toxicity |
摘要 |
The present invention relates to a compound to selectively kill or protect a target cell in a patient with reduced systemic toxicity, which comprises a compound of the formula: W-Z-X wherein, X is a toxic agent or protective agent; W is a biologically active molecule which is adapted to selectively bind the target cell directly or indirectly; and Z is a breakable linker which covalently links W and X together, wherein the linked W remains bioavailable and bioactive, whereby the breakable linker releases the toxic agent or protective agent into the cell.
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申请公布号 |
US2004115209(A1) |
申请公布日期 |
2004.06.17 |
申请号 |
US20030600623 |
申请日期 |
2003.06.20 |
申请人 |
SARAGOVI URI H;GUILLEMARD VERONIQUE |
发明人 |
SARAGOVI URI H;GUILLEMARD VERONIQUE |
分类号 |
A61K47/48;(IPC1-7):A61K48/00;A61K39/395;A61K31/525 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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