PROCESS FOR PREPARATION OF PACLITAXEL TRIHYDRATE AND DOCETAXEL TRIHYDRATE

摘要

A process for the preparation of paclitaxel trihydrate and doctaxel trihydrate comprising (a) treating taxane selected from paclitaxel and docetaxel with a mixture of alkane and chlorinated alkane to obtain a crude product of 65-75% assay, (b) dissolving the crude product thus obtained in alkyl ketone followed by slow addition of an alkane to increase chromatographic purity, (c) dissolving the taxane of step (b) in an aliphatic nitrile at a temperature of 50-70° C., (d) adding purified water to the product of step (c) to precipitate taxane trihydrate; and (e) filtering and drying the product of step (d) to obtain taxane trihydrate of C.P. >99.5% and 98-102% assay.