| 摘要 |
The present invention relates to compositions an methods for regulating an immune response in a subject, particularly to treat a subject with a tumor, notably a solid tumor, or an infectious disease.. Disclosed are methods of regulating the innate immunity in a subject, such as by regulating the activity of .gamma..delta. T cells in a subject. Disclosed are combinations of a cytokine (IL-2) and a .gamma..delta. .TAU. cell activator, particular administration regimens and dosages can produce a remarkable expansion of .gamma..delta. T cells in vivo and a remarkable increase in a subject's immu ne defense.Prefered .gamma..delta. T cell activators include BrHPP (Bromohydrin PyroPhosphate or Phosphostim), CBrHPP, HDMAPP,CHDMAPP and Epox-PP.
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