INTERLEUKIN-1b-CONVERTING ENZYME INHIBITORS, PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF DISEASES

摘要

The present invention relates to novel classes of compounds which are inhibitors of interieukin-1 beta converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents againstinterieukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interieukin-1 mediated diseases using the compounds and compositions of this invention.