PSORIASIS DIAGNOSTICS AND THERAPEUTICS

摘要

This invention relates to polymorphisms in the human epidermal gene cluster in the major histocompatability complex. In particular, the invention relates to four polymorphisms in the sequence of the alpha-helix coiled-coil rod homologue (HCR) gene, the structure of the corresponding allelic polypeptides encoded thereby, and the similarity of these polypeptides with streptococcal surface antigen M proteins. The invention provides diagnostic assays for, and methods of manufacture of medicaments for both prophylaxis and treatment of guttate psoriasis and/or psoriasis vulgaris.