SPHEROIDAL HDL PARTICLES WITH A DEFINED PHOSPHOLIPID COMPOSITION

摘要

A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I): A is H, R, or each of Ar₁, Ar₂, and Ar₃, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R₁, R₂, R₃, R₄, R₅, and R₆, independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH₂, C(O)NHR, C(O)NRR', ROH, ROR', RSH, RSR', ROC(O)R'OH, NHR, NRR', RNHR', or RNR'R''; or R₁ and R₂ together, R₃ and R₄ together, or R₅ and R₆ together are ORO; wherein each of R, R', and R'', independently is C₁~C₆ alkyl; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.