| 发明名称 |
MAPKS AS MODIFIERS OF THE RAC, AXIN, AND BETA-CATENIN PATHWAYS AND METHODS OF USE |
| 摘要 |
Human MAPK genes are identified as modulators of the Rac, axin, and beta- catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.
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| 申请公布号 |
CA2506707(A1) |
申请公布日期 |
2004.06.10 |
| 申请号 |
CA20032506707 |
申请日期 |
2003.11.24 |
| 申请人 |
EXELIXIS, INC. |
发明人 |
LICKTEIG, KIM;FRANCIS, GEORGE ROSS;KADYK, LISA C.;GENDREAU, STEVEN BRIAN;COSTA, MICHAEL R.;DORA, EMERY G., III |
| 分类号 |
A61K31/00;C12Q1/48;(IPC1-7):C12Q1/18;G01N33/53 |
主分类号 |
A61K31/00 |
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