MAPKS AS MODIFIERS OF THE RAC, AXIN, AND BETA-CATENIN PATHWAYS AND METHODS OF USE

摘要

Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.