METHODS FOR COHORT SELECTION AND LONGEVITY STUDIES
摘要
This application includes methods and compositions for evaluating a genetic locus associated with longevity and methods for evaluating information from groups of individuals. A longevity-associated locus was identified in gene that encodes for the microsomal triglyceride transfer (MTP) protein on chromosome IV. The polymorphic markers in the region and their methods of use are described. Also disclosed is a method for evaluating information which information for each individual of a first group of individuals and each individual of a second group of individuals is used to select a subset of individuals from the second group. The information can be about a plurality of different biological features. The selection can use a comparison between information for members of the first group and information for members of the subset. It is also possible to compare members of the first group to members of the selected subset with respect to at least one factor. The method can be used to reduce stratification, for example, in the analysis of genetic associations.