THERAPEUTIC AGENT FOR RESPIRATORY DISEASE CONTAINING 4-HYDROXYPIPERIDINE DERIVATIVE AS ACTIVE INGREDIENT

摘要

A preventive/therapeutic agent for respiratory diseases which contains as an active ingredient either a compound represented by the following formula (I): (I) wherein A is a group represented by L-W [L is a bond or CH2 and W is oxygen, SOn (n is 0 to 2), or -NR<7>- (R<7> is hydrogen or lower alkyl)]; G<1> and G<2> each is (CH2)r (r is 0 to 2), provided that when n is 1, then G<1> and G<2> may be bridged by lower alkylene; Y is lower alkylene or (substituted) benzylidene and Z is a bond or oxygen, provided that when Z is a bond, then Y may form a 5- or 6-membered ring in cooperation with carbon atoms of the benzene ring; R<1> is NO2, lower alkoxycarbonyl, (substituted) carbamoyl, (protected) hydroxy, (protected) carboxy, (protected) N-hydroxycarbamoyl, etc.; R<2> and R<3> each is hydrogen, halogeno, (halogenated) lower alkyl, (halogenated) lower alkoxy, or NO2; R<4> and R<5> each is hydrogen, halogeno, (halogenated) lower alkyl, CN, lower alkylsulfonyl, etc.; and R<6> is hydrogen or lower alkyl) or a salt or solvate of the compound. It has excellent antitussive activity when used as a preventive/therapeutic agent for respiratory diseases such as lung cancer, common cold syndrome, pulmonary tuberculosis, pneumonia, acute bronchitis, and chronic bronchitis.