METHOD OF HYDROGENATION REACTION

摘要

A method of heterogeneous catalytic hydrogenation reaction by means of a solid catalyst packed reaction column adapted to cause hydrogen gas and a liquid phase containing a substance to be hydrogenated to flow downward in parallel current from up above, wherein under perfusion conditions, the dynamic liquid phase retention volume per unit catalyst contour surface area of catalyst charged in the reaction column is in the range of 0.005 x 10<-3> to 0.14 x 10<-3> m<3>/m<2> while the catalyst strength calculated by the formula A-2sigma [A represents the average of minimum crush strengths measured with respect to 100 units of the catalyst in accordance with the "crush strength testing method" described in JIS Z8841-1993, and sigma represents the standard deviation value thereof] is 1.0 kg or greater.