发明名称 |
METHOD FOR INACTIVATING ENDOTOXIN IN FAT EMULSION OR IN LIPOSOME PREPARATION |
摘要 |
PROBLEM TO BE SOLVED: To provide an industrially advantageous method for inactivating endotoxin activity in a fat emulsion for the purpose of supplying nutrition to be administered to a human or in a liposome preparation used for a drug delivery system. SOLUTION: This method for inactivating the endotoxin in the fat emulsion or liposome preparation is characterized by heat-treating the fat emulsion or liposome preparation at 100-125°C. The heating time in this case is 5-60 min to complete the purpose, and a generally used heating device such as an autoclave can be adopted. In the fat emulsion or liposome preparation, other components such as glucose can be co-present as far as not causing coagulation by mixing them. COPYRIGHT: (C)2004,JPO
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申请公布号 |
JP2004155771(A) |
申请公布日期 |
2004.06.03 |
申请号 |
JP20030344647 |
申请日期 |
2003.10.02 |
申请人 |
OTSUKA PHARMACEUT FACTORY INC |
发明人 |
HIRATA TAKEKI;AOKI MITSUO |
分类号 |
A61K9/107;A61K9/127;A61K47/10;A61K47/14;A61K47/18;A61P7/08;A61P39/00;(IPC1-7):A61K9/107 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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