New 10-benzylidene-1,8-dichloro-9(10H)-anthracenone derivatives are potent tubulin polymerization inhibitors used for treating proliferative diseases, especially cancer

摘要

10-Benzylidene-1,8-dichloro-9(10H)-anthracenone derivatives (I) are new. 10-Benzylidene-1,8-dichloro-9(10H)-anthracenone derivatives of formula (I) are new. R1-R5 = H, 1-6C alkoxy, 1-6C alkyl, COOH, SO3H, SO3M, ester or thioester group, CN, acyl, aryloxy, phenylmethoxy, NO2, OH, amino, imino, SH, OP(O)(OM)2, NP(O)(OM)2 or NP(O)(OR)2; M = cation, and R = 1-8C alkyl, benzyl or aryl.