PROCESS FOR PRODUCING CARBAPENEM COMPOUND FOR ORAL ADMINISTRATION

摘要

A process for efficiently producing a 1beta-methylcarbapenem compound for oral administration. The process, which is for producing a 1beta-methylcarbapenem compound represented by the general formula (2), is characterized by reacting a beta-lactam compound represented by the general formula (1) as a starting material with a thiol compound (R3-SH) in the presence of a base and optionally eliminating the protective group R1. (1) (2) (In the formulae, R1 represents hydrogen, trimethylsilyl, or triethylsilyl; R2 represents C1-10 alkyl or C3-10 cycloalkyl; R3 represents an organic group; and R4 represents hydrogen, trimethylsilyl, or triethylsilyl.)