SURFACE DISSOLUTION AND/OR BULK EROSION CONTROLLED RELEASE COMPOSITIONS AND DEVICES

摘要

The present invention relates to a controlled release system comprising matrix compositions which control the lag time and release rate of the composition, as well as pharmaceutical and other active ingredients included in the compositions, through surface dissolution and/or bulk erosion of the system. The controlled release system can be used to target and control the release of active ingredients onto certain regions of the gastrointestinal tract including the stomach and small intestine. The matrix compositions of the present invention can be comprised of the following components: a wax material, fat material, water sensitive material and surface active material.