摘要 |
The present inventors have discovered that Trehalose-6-Phosphate Synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of Trehalose-6-Phosphate Synthase gene expression in fungi results in reduced pathogenicity (i.e. smaller, non-viable lesions). Thus, Trehalose-6-Phosphate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Trehalose-6-Phosphate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals. |
申请人 |
PARADIGM GENETICS, INC.;DARVEAUX, BLAISE;MAHANTY, SANJOY;HEINIGER, RYAN;COVINGTON, AMY;PAN, HUAQUIN;TARPEY, REX;SHUSTER, JEFFREY;TANZER, MATTHEW, M.;HAMER, LISBETH;ADACHI, KIICHI;DEZWANN, TODD, M.;LO, SZE-CHUNG;MONTENEGRO-CHAMORRO, MARIA, VICTORIA;FRANK, SHERYL |
发明人 |
DARVEAUX, BLAISE;MAHANTY, SANJOY;HEINIGER, RYAN;COVINGTON, AMY;PAN, HUAQUIN;TARPEY, REX;SHUSTER, JEFFREY;TANZER, MATTHEW, M.;HAMER, LISBETH;ADACHI, KIICHI;DEZWANN, TODD, M.;LO, SZE-CHUNG;MONTENEGRO-CHAMORRO, MARIA, VICTORIA;FRANK, SHERYL |