DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN ENDOTHELIAL DIFFERENTIATION, SPHINGOLIPID G-PROTEIN-COUPLED RECEPTOR 5 (EDG5)

摘要

The invention provides a human EDG5 which is associated with the cardio-vascular diseases, disorders of the gastroenterology system, reproduction diseases, disorders of the peripheral and central nervous system and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardio-vascular diseases, disorders of the gastroenterology system, reproduction diseases, disorders of the peripheral and central nervous system and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of EDG5 as well as pharmaceutical compositions comprising such compounds.