发明名称 |
MUTANT PROTEINASE INHIBITORS AND USES THEREOF |
摘要 |
A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, a mutant proteinase inhibitor can be obtained that has the amino acid sequence of a wild-type protein, or an active fragment therof, save for the presence of one or more mutations in at least one epitope, thereby altering interaction of the mutant with an anti-proteinase inhibitor antibody.
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申请公布号 |
WO03053921(A9) |
申请公布日期 |
2004.05.13 |
申请号 |
WO2002US22822 |
申请日期 |
2002.07.18 |
申请人 |
AMERICAN RED CROSS;WYETH;LAWRENCE, DANIEL, A.;GORLATOVA, NATALIA;CRANDALL, DAVID, L. |
发明人 |
LAWRENCE, DANIEL, A.;GORLATOVA, NATALIA;CRANDALL, DAVID, L. |
分类号 |
G01N33/50;A61K45/00;A61P43/00;C07K14/81;C07K16/38;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/48;C12N15/09;C12P21/02;C12Q1/37;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C07D/ |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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