BIODEGRADABLE SUBSTRATE, PROSTHETIC MATERIAL FOR TISSUE REGENERATION AND CULTURED TISSUE

摘要

A biodegradable substrate usable as a prosthetic material for medicinal use (for example, tissue regeneration) or a cell culture substrate which is highly compatible with cells, in particular, facilitates the invasion of cells into the inside of the substrate and has a thick structure similar to woven fabrics without resort to any troublesome techniques such as lamination or weaving/knitting. The biodegradable substrate is obtained by stitching a biodegradable nonwoven fabric with a biodegradable threadlike article. As the nonwoven fabric, use is made of, for example, a material wherein first and second layers, each having filaments of a threadlike article made of collagen located in parallel, are laminated and adhered to each other so that the alignment direction of the filaments of the threadlike aritcle in the first layer and that of the second layer are arranged at a certain angle. This nonwoven fabric is stitched with a threadlike article made of collagen. It is also possible that a filmy material having been treated with a biodegradable binder such as collagen or gelatin is piled on the nonwoven fabric and stitched.