发明名称 |
Antigenic constructs of major histocompatibility complex class I antigens with specific carrier molecules, the preparation and use thereof |
摘要 |
Antigenic constructs which result from linkage of major histocompatibility complex (MHC) class I antigens with specific carrier molecules are described. The linkage is effected N- or C-terminally by covalent bonding or, in the case of non-covalent bonding, for example by an avidin/biotin bridge. The specific carrier molecules bind selectively to target cells and are preferably monoclonal antibodies. Processes of genetic manipulation for the preparation of such constructs are indicated. Antigenic constructs according to the invention are used to damage or eliminate target cells.
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申请公布号 |
US2004091488(A1) |
申请公布日期 |
2004.05.13 |
申请号 |
US20030412672 |
申请日期 |
2003.04.14 |
申请人 |
DR. KLAUS BOSSLET |
发明人 |
SEEMAN GERHARD;BOSSLET KLAUS;SEDLACEK HANS HARALD |
分类号 |
C12P21/00;A61K38/00;A61K39/00;A61K39/395;A61K47/48;C07K14/00;C07K14/74;C07K16/00;C07K16/46;C07K17/02;C07K19/00;C12N15/09;C12P21/08;C12R1/91;(IPC1-7):A61K39/395 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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