| 发明名称 |
Aromatic sulfone hydroxamates and their use as protease inhibitors |
| 摘要 |
<p>This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.</p> |
| 申请公布号 |
CZ20032913(A3) |
申请公布日期 |
2004.05.12 |
| 申请号 |
CZ20030002913 |
申请日期 |
2002.05.10 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
BARTA THOMAS E.;BECKER DANIEL P.;BEDELL LOUIS J.;BOEHM TERRI L.;CARROLL JEFFERY N.;DECRESCENZO GARY A.;FOBIAN YVETTE M.;FRESKOS JOHN N.;HOCKERMAN SUSAN L.;KASSAB DARREN J.;KOLODZIEJ STEVE A.;MCDONALD JOSEPH J.;MISCHKE DEBORAH A.;NORTON MONICA B.;RICO JOSEPH G.;TALLEY JOHN J.;VILLAMIL CLARA I.;WANG LIJUAN JANE |
| 分类号 |
C07D491/048;A61K31/35;A61K31/351;A61K31/357;A61K31/381;A61K31/397;A61K31/4025;A61K31/404;A61K31/41;A61K31/4178;A61K31/4184;A61K31/42;A61K31/423;A61K31/4245;A61K31/427;A61K31/428;A61K31/4355;A61K31/4433;A61K31/445;A61K31/453;A61K31/454;A61K31/4545;A61K31/455;A61K31/4709;A61K31/4725;A61K31/506;A61K31/53;A61K31/5377;A61P1/02;A61P1/04;A61P1/16;A61P7/00;A61P7/02;A61P7/04;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P13/12;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P25/00;A61P25/18;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P31/04;A61P35/00;A61P35/04;A61P37/02;A61P37/06;A61P39/00;A61P43/00;C07D211/66;C07D309/08;C07D309/12;C07D401/12;C07D405/12;C07D405/14;C07D407/12;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D491/04;(IPC1-7):C07D309/08;A61K31/446;A61K31/442 |
主分类号 |
C07D491/048 |
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