摘要 |
Compounds having the formula (1): <CHEM> wherein R<1> represents an alkyl or alkenyl group, R<2> and R<3> each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R<2> and R<3> may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represents a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to pharmaceutical compositions containing them. These compounds have inhibitory activity against IL-1 beta production, high water solubility and good oral absorbability.
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