| 发明名称 |
ALKYNE DERIVATIVES AS TRACERS FOR METABOTROPIC GLUTAMATE RECEPTOR BINDING |
| 摘要 |
The present invention is directed to isotopically labeled alkyne derivative compounds, particularly <11>C, <13>C, <14>C, <18>F, <15>O, <13>N, <35>S, <2>H, and <3>H labeled compounds. In particular, the present invention is directed to <11>C, <13>C, <14>C, <18>F, <15>O, <13>N, <35>S, <2>H, and <3>H labeled heterocyclic alkynes and methods of their preparation. The present invention further includes a method of use of the <11>C, <18>F, <15>O, or <13>N labeled heterocyclic alkyne compounds as tracers in positron emission tomography (PET) imaging, particularly in the study of metabolic conditions in mammals, specifically conditions modulated by metabotropic glutamate receptors subtype 5 (mGluR5). |
| 申请公布号 |
WO2004038374(A2) |
申请公布日期 |
2004.05.06 |
| 申请号 |
WO2003US33613 |
申请日期 |
2003.10.24 |
| 申请人 |
MERCK & CO., INC.;COSFORD, NICHOLAS, DAVID, PETER;GOVEK, STEVEN, PATRICK;HAMILL, TERENCE, GERARD;KAMENECKA, THEODORE;ROPPE, JEFFREY, ROGER;SEIDERS, THOMAS, JONATHAN |
发明人 |
COSFORD, NICHOLAS, DAVID, PETER;GOVEK, STEVEN, PATRICK;HAMILL, TERENCE, GERARD;KAMENECKA, THEODORE;ROPPE, JEFFREY, ROGER;SEIDERS, THOMAS, JONATHAN |
| 分类号 |
A61K51/04;A61P35/00;C07D213/22;C07D213/65;C07D277/30;C07D417/06;C07D417/14 |
主分类号 |
A61K51/04 |
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