CONJUGATES OF TC COMPLEXES AND TARGETING MOIETIES AND THEIR USE IN MRI DIAGNOSTIC
摘要
<p>The present invention relates to improved <99m>Tc radiometal complex compositions of aza-diaminedioxime ligands, together with radiopharmaceutical preparations containing them, and kits for the preparation of the radiopharmaceuticals. The technetium metal complexation chemistry of aza-diaminedioxime-targeting molecule chelator conjugates is shown to give rise to a multiplicity of technetium species. The present invention provides an improved aza-diaminedioxime conjugate technetium metal complex composition in which the presence of the less desirable technetium species is suppressed.</p>
申请公布号
WO2004037297(A1)
申请公布日期
2004.05.06
申请号
WO2003GB04573
申请日期
2003.10.24
申请人
AMERSHAM PLC;BRAUERS, GEORG;FARRAR, GILLIAN;BARNETT, DAVID, JONATHAN;WADSWORTH, HARRY, JOHN;LEWIS, JOANNE, SARAH
发明人
BRAUERS, GEORG;FARRAR, GILLIAN;BARNETT, DAVID, JONATHAN;WADSWORTH, HARRY, JOHN;LEWIS, JOANNE, SARAH