| 摘要 |
A method is described for the preparation of aryl-pyridine compounds of formula (I) by cross-coupling reaction, promoted by catalytic systems based on palladium or nickel between compounds of formula (II) and (III) in which: - Met represents Mg or Zn, - Y represents C1, Br, I or acetoxy, - Z represents I, Br, Cl, triflate, sulphonate, phosphate, - Rl, R2, R3, R4, which are the same as one another or different, represent hydrogen, a linear and/or branched Cl-C4 alkyl, and/or an aryl, and/or a heteroaryl, or Rl and R2 and/or R3and R4, taken together, form a C3-C8 ring, an aryl and/or a heteroaryl, - A represents -COR5 where R5 represents hydrogen, a linear and/or branched Cl-C4 alkyl, and/or an aryl, and/or a heteroaryl, or - A represents -CRs5(OR6)(OR7) where R5 has the meaning described above and R6 and R7, which are the same as one another or different, represent a linear and/or branched C1-C4 alkyl, and/or an aryl, and/or a heteroaryl, or R6 and R7, joined together, represent a C1-C8 alkyl or alkenyl. |
