发明名称 |
Diagnostic and therapeutic use of the nicotinamide mononucleotide adenylytransferase 2 (nmnat-2) gene and protein for neurodegenerative diseases |
摘要 |
The present invention discloses the differential expression of a gene coding for Ensadin-0625 in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the Ensadin-0625 gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed. |
申请公布号 |
AU2003294696(A8) |
申请公布日期 |
2004.05.04 |
申请号 |
AU20030294696 |
申请日期 |
2003.10.16 |
申请人 |
EVOTEC NEUROSCIENCES GMBH |
发明人 |
HEINZ VON DER KAMMER;JOHANNES POHLNER |
分类号 |
A01K67/027;A61K38/45;C07K16/40;C12N9/12;C12N15/00;C12Q1/48;C12Q1/68;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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