发明名称 |
LOCAL DELIVERY OF 17-BETA ESTRADIOL FOR PREVENTING VASCULAR INTIMA HYPERPLASIA AND FOR IMPROVING VASCULAR ENDOTHELIUM FUNCTION AFTER VASCULAR INJURY |
摘要 |
The cardioprotective effects of estrogen are well recognized. In in vitro experiments, and upon systemic administration, 17-beta estradiol has shown t o inhibit vascular smooth muscle cell proliferation and intima hyperplasia and to improve vascular endothelium function, after vascular injury. We hypothesized that locally delivered 17-beta estradiol could prevent restenosis. Compositions are use of 17-beta estradiol for in-situ administration at a vascular injured site are objects of the present inventi on.
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申请公布号 |
CA2381031(C) |
申请公布日期 |
2004.05.04 |
申请号 |
CA20002381031 |
申请日期 |
2000.09.21 |
申请人 |
INSTITUT DE CARDIOLOGIE DE MONTREAL |
发明人 |
TANGUAY, JEAN-FRANCOIS;CHANDRASEKAR, BASKARAN |
分类号 |
A61K31/565;(IPC1-7):A61K31/565;A61P41/00 |
主分类号 |
A61K31/565 |
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