| 摘要 |
Described is a process for preparing crystalline particles of a substance suitable for inhalation therapy, which comprises (i) admitting a stream of solution of the substance in a liquid solvent and a stream of liquid antisolvent for the substance, which is miscible with the liquid solvent, tangentially into the cylindrical mixing chamber having an axial port such that the streams are intimately mixed through formation of a vortex and precipitation of crystalline particles is caused, and (ii) collecting the resultant crystalline particles suspended in the stream of liquid discharged from the outlet port of the mixing chamber. Also described is an apparatus suitable for the above method, comprising a first reservoir of the substance dissolved in a liquid solvent; a second reservoir of liquid antisolvent for the substance, which is miscible with the liquid solvent; a cylindrical mixing chamber having first and second tangential inlet ports and an axial outlet port; means for delivering the contents of the first and second reservoirs to the mixing chamber in a stream via the inlet ports, wherein the streams are intimately mixed through the formation of a vortex; and means for collecting crystalline particles suspended in the stream of liquid discharged form the outlet port of the mixing chamber.
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