发明名称 |
ABERRANTLY METHYLATED GENES AS MARKERS OF BREAST MALIGNANCY |
摘要 |
The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid receptor beta (RARss), estrogen receptor (ER), cyclin D2, WT-1, 14.3.3 SIGMA, HIN-1, RASSF1A, and combinations of such genes serve as markers of breast malignancy. |
申请公布号 |
WO02059347(A3) |
申请公布日期 |
2004.04.29 |
申请号 |
WO2002US02455 |
申请日期 |
2002.01.28 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
SUKUMAR, SARASWATI;EVRON, ELLA;DOOLEY, WILLIAM, C.;SACCHI, NICOLETTA;DAVIDSON, NANCY;FACKLER, MARY, JO |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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