Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres

摘要

Preparation of 1,4-diamino-2-methoxymethylbenzene (I) and its salts comprises reacting 2-methoxymethyl-4-nitrophenol with haloacetamide to give 2-(2-methoxymethyl-4-nitrophenoxy)acetamide, heating to 80-120 degrees C in DMF, DMAc or NMP with excess of carbonate to give 2-methoxymethyl-4-nitroaniline and catalytically hydrogenating to give (I) and optionally reacting with an acid to give an acid adduct. Preparation of 1,4-diamino-2-methoxymethylbenzene (I) and its salts comprises reacting 2-methoxymethyl-4-nitrophenol with a haloacetamide to give 2-(2-methoxymethyl-4-nitrophenoxy)acetamide, heating to 80-120 degrees C in a solvent from DMF, DMAc and NMP with an excess of carbonate to give 2-methoxymethyl-4-nitroaniline and catalytically hydrogenating to give (I) and optionally reacting with an acid to give an acid adduct when n is not 0. n = 0-2; and HX = (in)organic acid.