发明名称 |
DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
摘要 |
A family of compounds of formula (I) wherein: X is one of the following radicals: which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer's disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease. |
申请公布号 |
WO2004032929(A2) |
申请公布日期 |
2004.04.22 |
申请号 |
WO2003GB04314 |
申请日期 |
2003.10.07 |
申请人 |
NEUROPHARMA SA;MARTINEZ GIL ANA;DORRONSORO DIAZ ISABEL;RUBIO ARRIETA LAURA;ALONSO GORDILLO DIANA;FUERTES HUERTA ANA;MORALES-ALCELAY SUSANA;DEL MONTE MILLAN MARIA;GARCIA PALOMERO ESTHER;USAN EGEA PAOLA;DE AUSTRIA CELIA;MEDINA PADILLA MIGUEL;RUFFLES GRAHAM KEITH |
发明人 |
MARTINEZ GIL ANA;DORRONSORO DIAZ ISABEL;RUBIO ARRIETA LAURA;ALONSO GORDILLO DIANA;FUERTES HUERTA ANA;MORALES-ALCELAY SUSANA;DEL MONTE MILLAN MARIA;GARCIA PALOMERO ESTHER;USAN EGEA PAOLA;DE AUSTRIA CELIA;MEDINA PADILLA MIGUEL |
分类号 |
A61K31/473;C07D219/12;C07D401/12;C07D417/12 |
主分类号 |
A61K31/473 |
代理机构 |
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代理人 |
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