| 发明名称 |
Isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof |
| 摘要 |
The present invention relates to isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent,wherein R1, R2, X and n are the same as defined in the specification.
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| 申请公布号 |
US6723724(B2) |
申请公布日期 |
2004.04.20 |
| 申请号 |
US20010839206 |
申请日期 |
2001.04.23 |
| 申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
KOH HUN YEONG;CHOI KYUNG IL;CHO YONG SEO;PAE AE NIM;KANG KYUNG HO;CHA MI YOUNG;KONG JAE YANG;JEONG DAE YOUNG;LEE HEE-YOON |
| 分类号 |
A61K31/454;A61K31/496;A61P25/00;A61P25/18;A61P43/00;C07D261/08;C07D413/04;C07D413/06;C07D413/14;(IPC1-7):A61K31/496 |
主分类号 |
A61K31/454 |
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