发明名称 |
Methods for identifying ligands using waterlogsy NMR |
摘要 |
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a test sample comprising at least one test compound; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the test sample and the target molecule; and comparing the WaterLOGSY spectra to determine if at least one test compound interacts with the target molecule with a binding affinity tighter than that of the reference compound.
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申请公布号 |
US2004072211(A1) |
申请公布日期 |
2004.04.15 |
申请号 |
US20030454898 |
申请日期 |
2003.06.05 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
DALVIT CLAUDIO |
分类号 |
G01N24/08;G01R33/32;G01R33/465;(IPC1-7):C12Q1/68;G01N33/53 |
主分类号 |
G01N24/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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