NUCLEIC ACID ISOLATED FROM THE 5' NON TRANSLATED REGION (5'NTR) END OF THE HUMAN FGF-1 GENE HAVING IRES ACTIVITY

摘要

The invention concerns an isolated nucleic acid of the human FGF-1 gene having IRES (internal ribosome entry site) activity, said nucleotide sequence being derived from the 5' non translated region (5'NTR) end of the human FGF-1 gene. The invention also concerns an expression cassette of at least one molecule of interest in a eukaryotic cell comprising at least one of said sequences. The cassette can be inserted directly or in the form of a vector in a host cell, hence the invention further concerns the recombinant vectors and the host cell transfected by said vector or the cassette.