PREVENTION OF PRIMARY SJOGREN'S SYNDROME BY ICA69 DEFICIENCY

摘要

This invention relates to identificatican of an autoantigen implicated in th e development and progression of Sjögren's Syndrome (pSS); particularly to the disease modifying effect of creating a deficiency in the ICA69 autoantigen; and most particularly to development of diagnostic and therapeutic avenues, means for the differential diagnosis of pSS versus other autoimmune disease, e.g. Systemic lupus erythematosis (SLE), and procedures for immunotherapeuti c treatment effective to alter the course and progression of pSS.