摘要 |
A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1'-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, with a base, followed by heating to give pyropheophorbide a, which is converted to HPPH by treatment with acid, followed by hexyl alcohol under basic conditions. |
申请人 |
HEALTH RESEARCH, INC.;LIGHT SCIENCES CORPORATION;PANDEY, RAVINDRA, K.;DOUGHERTY, THOMAS, J.;PALLENBERG, ALEXANDER, J. |
发明人 |
PANDEY, RAVINDRA, K.;DOUGHERTY, THOMAS, J.;PALLENBERG, ALEXANDER, J. |