发明名称 |
METHOD OF STRENGTHENING FOREIGN EPITOPE PRESENTATION BY MHC CLASS I BY INHIBITING TAP ACTIVITY |
摘要 |
A method of strengthening the presentation of a foreign epitope by MHC class I by inhibiting TAP activity. A mammalian cell-infecting viral vector encoding both of a TAP inhibitor and epitope-binding .beta.2m is constructed and transferred into mammalian cells. Thus, endogenous MHC class I/peptide complexes are decreased by the TAP inhibitor and MHC class I/peptide complex es containing epitope-binding .beta.2m expressed from the vector are successful ly presented on the cell surface at a high frequency. This method is useful in the vaccine therapy for infection and cancer.
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申请公布号 |
CA2500413(A1) |
申请公布日期 |
2004.04.15 |
申请号 |
CA20032500413 |
申请日期 |
2003.10.01 |
申请人 |
DNAVEC RESEARCH INC. |
发明人 |
IWAMOTO, AIKICHI;TACHIKAWA, AI |
分类号 |
A61P31/00;A61P35/00;A61P37/04;A61P43/00;C07K14/16;C07K14/74;(IPC1-7):C12N15/00;A61K38/00;A61K45/00;A61K48/00;C07K19/00;C12N5/00;C12P21/02;C12N5/10;C12N15/12;C12N15/62;C12N15/67 |
主分类号 |
A61P31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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