| 摘要 |
Aminobenzoic acid derivatives represented by Formula (1) as follows:(wherein, R<1 >represents a hydrogen atom, a C1-6alkyl group, or the like; R<2 >represents a hydrogen atom, a C1-6alkyl group, or the like; R<3 >represents a C8-25alkyl group, or the like; R<4 >represents a hydrogen atom or a group represented by OR<9 >or CO2R<10 >(wherein R<9 >and R<10 >represent a hydrogen atom or a C1-6 alkyl group); A represents a group represented by S(O)qR<15 >(wherein q is 0, 1, or 2, R<15 >represents a C1-6alkyl group, a phenyl C1-3alkyl group, or a group represented by (CH2)mOR<16 >(wherein m is 2 or 3, and R<16 >represents a hydrogen atom or a methoxymethyl group), or the like; X represents O, a single bond, CH=CH, or a group represented by NR<27 >(wherein R<27 >represents a hydrogen atom or a t-butoxycarbonyl group); Y represents O, CONH, NHCO, or a group represented by NR<28 >(wherein R<28 >represents a hydrogen atom or a t-butoxycarbonyl group); and n is an integer of 0 to 15)or pharmaceutically acceptable salts of the same are employed as VEGF receptor antagonists, and in particular as therapeutic agents for the diseases in which VEGF is involved.
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