发明名称 |
METHOD AND MATERIALS RELATING TO NEUROGENESIS |
摘要 |
Methods for promoting dopaminergic neuronal development and producing neural cells having a dopaminergic phenotype. Dopaminergic neural cells may be used for treating individuals having a neurodegenerative disease such as Parkinson's disease. Dopaminergic cells may be implanted into the brain of the individual, and/or dopaminergic neural development may be induced or enhanced in the brain of the individual. Methods comprise expressing a nuclear receptor of the NG4A subfamily, e.g. Nurr1, above basal levels within the cell and treating the cell with a Wnt ligand, thereby producing or enhancing proliferation, self-renewal, survival and/or dopaminergic induction, differentiation, survival or acquisition of a neuronal dopaminergic phenotype. The cell may be co-cultured with astrocytes or glial cells and may be contacted with an FGF growth factor. |
申请公布号 |
WO2004029229(A2) |
申请公布日期 |
2004.04.08 |
申请号 |
WO2003IB04598 |
申请日期 |
2003.09.24 |
申请人 |
NEURO THERAPEUTICS AB;ARENAS, ERNESTO;WAGNER, JOSEPH;BRANCO, GONCALO, CASTELO;SOUSA, KYLE |
发明人 |
ARENAS, ERNESTO;WAGNER, JOSEPH;BRANCO, GONCALO, CASTELO;SOUSA, KYLE |
分类号 |
A61K38/18;A61K48/00;A61P25/16;C12N5/0793;C12N15/06;G01N33/68;G01N33/94 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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