发明名称 |
METHODS OF CRYSTAL PRECIPITATION |
摘要 |
<p>A method of precipitating crystals of paroxetine hydrochloride 1/2-hydrate in a water-containing polar organic solvent, which comprises adding water to a solution or suspension of paroxetine hydrochloride in either a water-free polar organic solvent or a solvent containing up to 60 wt.% water to regulate the water content to 70 wt.% or higher and thereby precipitate crystals of paroxetine hydrochloride 1/2-hydrate. Also provided is a method of precipitating crystals of paroxethine hydrochloride 1/2-hydrate in water or a water-containing polar organic solvent, which comprises causing hydrogen chloride to be present in the system to thereby precipitate crystals of paroxetine hydrochloride 1/2-hydrate which have not been colored in pink.</p> |
申请公布号 |
WO2004026860(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
WO2003JP11805 |
申请日期 |
2003.09.17 |
申请人 |
SUMIKA FINE CHEMICALS CO., LTD.;YAMAZAKI, SHIGEYA;YOSHIKAWA, TAICHI |
发明人 |
YAMAZAKI, SHIGEYA;YOSHIKAWA, TAICHI |
分类号 |
C07D263/58;C07D405/12;(IPC1-7):C07D405/12 |
主分类号 |
C07D263/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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